MYOSAIQ dataset

A unique database

The overall MYOSAIQ dataset was created from real clinical exams acquired at the University Hospital of Lyon from different centers. Acquired data were fully anonymized and handled within the regulations set by the local ethical committee of the Hospital of Lyon (France).

The full dataset is composed of 439 LGE exams from two different cohorts to quantify MI lesions at different phases of the longitudinal evolution of the disease: 4-8 days post-MI (MIMI cohort) and 1 month / 12 months post MI & reperfusion (HIBISCUS cohort). This dataset is divided into 3 subgroups as follows:

  • 123 patients with LGE images of acute myocardial infarction up to 8 days post-MI (MIMI cohort). These patients were treated by two different procedures: i) with Percutaneous Coronary Intervention (PCI) and immediate stenting or ii) with the Minimalist Immediate Mechanical Intervention approach

  • 187 patients with LGE images obtained at 1 month post PCI and reperfusion (HIBISCUS-STEMI cohort);

  • 129 patients with LGE images obtained at 12 months post PCI and reperfusion (HIBISCUS-STEMI cohort);
A more detailed description of the protocols used to acquire the MIMI and HIBISCUS cohorts can be found at the end of this page.

In addition, we chose to keep all the data collected in the hospitals in order to integrate the heterogeneity present in this type of examination, i.e.
  • the presence of artefacts, visible in 15% of the exams;

  • the variability of the properties of the acquired images, due to the use of different acquisition techniques: 3D sequences and 2D PSIR sequences and due to the involvement of different centers;
More information on the systems used in our study can be found at the end of this page.

Patients population information

  • The MIMI cohort is composed of consecutive patients admitted to the XX french hospital, with ST-segment-elevation myocardial infarction ≤12 hours and randomized to immediate stenting (n=65) or delayed stenting (n=58) after Thrombolysis In Myocardial Infarction 3 flow restoration by thrombus aspiration. Patients in the DS group underwent a second coronary arteriography for stent implantation a median of 36 hours (interquartile range 29-46) after randomization. The primary end point was microvascular obstruction (% left ventricular mass) on cardiac magnetic resonance imaging performed 5 days (interquartile range 4-6) after the first procedure. There was a nonsignificant trend toward lower microvascular obstruction in the immediate stenting group compared with DS group (1.88% versus 3.96%; P=0.051), which became significant after adjustment for the area at risk (P=0.049). Median infarct weight, left ventricular ejection fraction, and infarct size did not differ between groups. No difference in 6-month outcomes was apparent for the rate of major cardiovascular and cerebral events.

  • The HIBISCUS-STEMI cohort is composed of consecutive patients admitted to the University Hospital of Lyon (HCL), a tertiary referral university hospital, with a suspicion of acute STEMI from 2016 to 2019. The study was approved by our institution Review Board and Ethics Committee. Three hundred patients were included. All patients gave written informed consent. STEMI was defined according to the European Society of Cardiology guidelines by the presence of clinical symptoms (chest pain) associated with an ST elevation of more than 2 mm in two contiguous leads on a standard 12-lead electrocardiogram, and significant troponin-I elevation. All patients underwent coronary angiography at admission with subsequent reperfusion by primary percutaneous intervention (PCI). All patients had a complete myocardial enzyme release assessment and underwent contrast enhanced Cardiac Magnetic Resonance (CMR) at one month after AMI. All individual clinical, treatment and outcome data have been stored prospectively in the database of the Centre for Clinical Investigation of Hospices Civils de Lyon. Adverse clinical events have been registered at follow-up visits scheduled at 1 month, 1 year and 2 years after the index hospitalization. A primary endpoint was defined as the composite of all-cause death, rehospitalization for heart failure, AMI and stroke.

Involved MR scanners and acquisition protocols

The acquisitions were obtained using 1.5T MRI scanners (Siemens Area, Siemens Medical Solutions, Germany). All patients were scanned in a supine position on a 1.5 T Siemens system (Aera or Avanto system). Cine free precession sequences in two-chamber, four-chamber, and ventricular short axis planes were used for quantitative ventricular measurements. Myocardial delayed enhancement sequences were assessed in short and long-axis planes with an inversion-recovery sequence 10-15 minutes after the administration of 0.2 mmol/kg gadolinium-based contrast agent. Depending on the patient capacity to hold his breath more than 16sec, a 3D sequence could be used or not. In any case two alternate sequence are available: i) the 2D Phase-sensitive inversion-recovery sequence (PSIR) which offer un-ambiguous remote-to-infarct contrast and ii) MOLLI sequence at some specific locations. Infarct size was measured using the CMRSegTools segmentation plugin (CREATIS, Lyon, France) with OsiriX software (Pixmeo, Geneva, Switzerland).